Comprehensive Coverage 139 Skills - Extensive coverage across all major scientific domains 28+ Databases - Direct access to OpenAlex, PubMed, bioRxiv, ChEMBL, UniProt, COSMIC, and more 55+ Python Packages - RDKit, Scanpy, PyTorch Lightning, scikit-learn, BioServices, PennyLane, Qiskit, and others

GitHub repository with 139 scientific skills for Claude, enabling complex multi-step research workflows across biology, chemistry, medicine, and other scientific domains

Star Trek's unproduced 'Phase II' series from the 1970s included 19 episode scripts that were never filmed via kottke.org

The trouble with these calculations is that they mire us in epistemically tricky terrain. I’m bothered by how quickly the discussions of AI become utopian or apocalyptic. ... It also forces thinking to be obsessively short term. People start losing interest in problems of the next five or ten years, because superintelligence will have already changed everything. The big political and technological questions we need to discuss are only those that matter to the speed of AI development. Furthermore, we must sprint towards a post-superintelligence world even though we have no real idea what it will bring.

Dan Wang's 2025 annual review letter.

I started my tools.simonwillison.net site last year as a single location for my growing collection of vibe-coded / AI-assisted HTML+JavaScript tools ... The new browse all by month page shows I built 110 of these in 2025!

Simon Willison's Annual review blog post examining major trends and developments in large language models (LLMs) during 2025.