Far too many diseases are still untreatable. It’s painful to imagine gradually forgetting your children’s names, forgetting how to hold a conversation, how to recognize your own home, and eventually even how to swallow food, while your family watches someone they love disappear. But that’s the reality for over thirty million people with Alzheimer’s globally, and we have almost nothing to offer them. Part of the reason may be because the brain is so complex, or because it’s lined by the blood-brain barrier, a tightly sealed layer of cells which keeps out most pathogens and toxins, as well as most drugs. That makes it challenging to design a drug that can cross the barrier, reach the right cells, and do what it’s meant to do without any unexpected side effects.

A gorgeous WIP article on medical innovation. A good reminder that intelligence is rarely the bottleneck to progress.

Every dog license New York City has issued since 2014 — 819,323 license records, 34,663 distinct names. Search a name to see where it sits in the long tail, filter by ZIP code, and browse breed and name heatmaps. Counts are license records (dogs renewing across years appear more than once).

New project! NYC Dog Name Explorer shows licensed dog name popularity across the city. Inspiration for this from John Cook

We're breaking five stories today based on verifiable financial data which everyone missed for years.

Effort.News automates investigative journalism with five verified financial stories via marginalrevolution.com

Why do I think I will be able to handle all scams in a few years, when I am already struggling to detect simple AI slop, increasingly ignore cold emails and have to write off whole swathes of social media as a source of information, and I can already see how eager all my peers are to offload all their thinking and writing to chatbot assistants unworthy of that trust, and how many projects or mailing lists have had to clamp down on unvetted contributions (eg. today as I write this, ⁠Project Ladybird)? In a few years, won’t I be the equivalent of a rich old person with declining faculties getting a call from the IRS about how I owe them fines, conveniently payable via gift cards…? And if not, why and how not—concretely?

Gwern announces Guardian Angels.