Far too many diseases are still untreatable. It’s painful to imagine gradually forgetting your children’s names, forgetting how to hold a conversation, how to recognize your own home, and eventually even how to swallow food, while your family watches someone they love disappear. But that’s the reality for over thirty million people with Alzheimer’s globally, and we have almost nothing to offer them. Part of the reason may be because the brain is so complex, or because it’s lined by the blood-brain barrier, a tightly sealed layer of cells which keeps out most pathogens and toxins, as well as most drugs. That makes it challenging to design a drug that can cross the barrier, reach the right cells, and do what it’s meant to do without any unexpected side effects.

A gorgeous WIP article on medical innovation. A good reminder that intelligence is rarely the bottleneck to progress.